Formation of an Intermediate in Prostaglandin Biosynthesis and Its Association with the Platelet Release Reaction
Authors:
- J. B. SmithJSJ. B. Smith
- Carol IngermanCICarol Ingerman
- J. J. KocsisJKJ. J. Kocsis
- M. J. SilverMSM. J. Silver
Open Access
- 1 May 1974
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 53 (5) , 1468-1472
Abstract
A compound that could be converted to prostaglandin F2α by mild chemical reduction was formed by human platelets in response to arachidonic acid, collagen, or L-epinephrine. It was present in maximal amounts at about 1 min after addition of arachidonic acid or collagen to platelet-rich plasma. Its initial formation appeared to precede platelet aggregation by these agents and was closely correlated with the release of adenine nucleotides and radioactive 5-hydroxytryptamine from platelets. Moreover, the compound was itself found outside the platelets. This compound is probably an endoperoxide intermediate in prostaglandin biosynthesis and may be a trigger for the platelet release reaction.Keywords
This publication has 17 references indexed in Scilit:
- Formation of Prostaglandins during the Aggregation of Human Blood PlateletsJournal of Clinical Investigation, 1973
- Prostaglandin production by mouse fibrosarcoma cells in culture: Inhibition by indomethacin and aspirinBiochemical and Biophysical Research Communications, 1972
- Extraction of Prostaglandins from Human BloodNature, 1971
- THE RELEASE OF PROSTAGLANDINS FROM LUNG AND OTHER TISSUESAnnals of the New York Academy of Sciences, 1971
- MECHANISM OF PROSTAGLANDIN BIOSYNTHESIS 18O2 STUDIES ON PGF1αAnnals of the New York Academy of Sciences, 1971
- Formation and release of prostaglandins by platelets in response to thrombin.1970
- Relationship between chemical structure and plateletaggregation activity of prostaglandinsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969
- The effect of salicylates on the hemostatic properties of platelets in manJournal of Clinical Investigation, 1968
- The release of nucleotides, 5‐hydroxytryptamine and enzymes from human blood platelets during aggregationThe Journal of Physiology, 1968
- Effect of Adenosine Derivatives and Antihistaminics on Platelet AggregationExperimental Biology and Medicine, 1966