RBMX is a novel hepatic transcriptional regulator of SREBP‐1c gene response to high‐fructose diet
Authors:
- Yoshihiko NishioYNYoshihiko Nishio
- Hiroshi MaegawaHMHiroshi Maegawa
- 14 December 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 581 (2) , 218-222
Abstract
In rodents a high‐fructose diet induces metabolic derangements similar to those in metabolic syndrome. Previously we suggested that in mouse liver an unidentified nuclear protein binding to the sterol regulatory element (SRE)‐binding protein‐1c (SREBP‐1c) promoter region plays a key role for the response to high‐fructose diet. Here, using MALDI‐TOF MASS technique, we identified an X‐chromosome‐linked RNA binding motif protein (RBMX) as a new candidate molecule. In electrophoretic mobility shift assay, anti‐RBMX antibody displaced the bands induced by fructose‐feeding. Overexpression or suppression of RBMX on rat hepatoma cells regulated the SREBP‐1c promoter activity. RBMX may control SREBP‐1c expression in mouse liver in response to high‐fructose diet.Keywords
This publication has 23 references indexed in Scilit:
- Single Nucleotide Polymorphism (–468 Gly to Ala) at the Promoter Region of Sterol Regulatory Element-binding Protein-1c Associates with Genetic Defect of Fructose-induced Hepatic LipogenesisJournal of Biological Chemistry, 2004
- The PGC-1-related Protein PERC Is a Selective Coactivator of Estrogen Receptor αJournal of Biological Chemistry, 2002
- Peroxisome Proliferator-activated Receptor γ Coactivator 1β (PGC-1β), A Novel PGC-1-related Transcription Coactivator Associated with Host Cell FactorJournal of Biological Chemistry, 2002
- RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicingHuman Molecular Genetics, 2000
- The roles of heterogeneous nuclear ribonucleoproteins (hnRNP) in RNA metabolismBioEssays, 1996
- hnRNP G: sequence and characterization of a glycosylated RNA-binding proteinNucleic Acids Research, 1993
- A novel 43-kDa glycoprotein is detected in the nucleus of mammalian cells by autoantibodies from dogs with autoimmune disordersExperimental Cell Research, 1991
- Heterogeneous Nuclear Ribonucleoproteins: Role in RNA SplicingScience, 1986
- Hyperinsulinemia in fructose-induced hypertriglyceridemia in the ratMetabolism, 1980
- Diabetes induced by a high fructose dietMetabolism, 1977