Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells
Authors:
- 21 May 2019
- journal article
- research article
- Published by Springer Nature in Journal of Neuro-Oncology
- Vol. 143 (3) , 417-428
Abstract
Glioblastoma (GBM) is the most aggressive adult brain cancer, with a 15 month median survivorship attributed to the existence of treatment-refractory brain tumor initiating cells (BTICs). In order to better understand the mechanisms regulating the tumorigenic properties of this population, we studied the role of the polycomb group member BMI1 in our patient-derived GBM BTICs and its relationship with CD133, a well-established marker of BTICs.Keywords
Funding Information
- Terry Fox Research Institute (1010)
This publication has 61 references indexed in Scilit:
- Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and CancerCell Stem Cell, 2010
- Role of the polycomb group gene BMI1 in normal and leukemic hematopoietic stem and progenitor cellsCurrent Opinion in Hematology, 2010
- BMI1 Sustains Human Glioblastoma Multiforme Stem Cell RenewalThe Journal of Neuroscience, 2009
- Bmi1 Controls Tumor Development in an Ink4a/Arf-Independent Manner in a Mouse Model for GliomaCancer Cell, 2007
- Cancer stem cells in solid tumorsCurrent Opinion in Biotechnology, 2007
- RETRACTED: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during DevelopmentCell Stem Cell, 2007
- Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitionsGenes & Development, 2006
- Stem Cells and CancerCell, 2004
- Bmi-1 determines the proliferative capacity of normal and leukaemic stem cellsNature, 2003
- Characterization and chromosomal localization of the human proto-oncogene BMI-1Human Molecular Genetics, 1993