Diastereoselective Mukaiyama and Free Radical Processes for the Synthesis of Polypropionate Units
Authors:
- 30 June 2004
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (15) , 2599-2602
Abstract
[reaction: see text] Reported herein is the synthesis of 8 out of 16 polypropionates derived from our propionate units. A new strategy involving a stereoselective Mukaiyama aldol reaction followed by a stereoselective free-radical-based hydrogen transfer, both under Lewis acid control, is used. Of particular interest is the remarkable reactivity of (i-PrO)TiCl(3) in this context to give only the 3,4-anti bromoesters.Keywords
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