Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawal
Open Access
- 1 January 2009
- journal article
- Published by Springer Nature in BMC Genomics
- Vol. 10 (1) , 261
Abstract
The molecular mechanisms of cell cycle exit are poorly understood. Studies on lymphocytes at cell cycle exit after growth factor deprivation have predominantly focused on the initiation of apoptosis. We aimed to study gene expression profile of primary and immortalised IL-2-dependent human T cells forced to exit the cell cycle by growth factor withdrawal, before apoptosis could be evidenced.Keywords
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