Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms
- 12 November 2019
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 91 (24) , 15732-15739
Abstract
Despite the recent technological advances in Fourier transform mass spectrometry (FTMS) instrumentation, top-down proteomics (TDP) is currently mostly applied to the characterization of proteoforms 30 kDa identified on the liquid chromatography time scale.Keywords
Funding Information
- National Institute of General Medical Sciences (P41 GM108569)
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