Silver(I)‐Catalyzed N‐Trifluoroethylation of Anilines and O‐Trifluoroethylation of Amides with 2,2,2‐Trifluorodiazoethane
Authors:
- 10 September 2015
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 54 (48) , 14503-14507
Abstract
A straightforward N‐trifluoroethylation of anilines has been developed based on silver‐catalyzed NH insertions with 2,2,2‐trifluorodiazoethane (CF3CHN2). Mechanistically, the reaction is proposed to involve migratory insertion of a silver carbene as the key step. In contrast, when amides are employed as the substrates under similar reaction conditions, O‐trifluoroethylation occurs to afford trifluoroethyl imidates.Keywords
Funding Information
- National Basic Research Program of China (2012CB821600)
- NSFC (21472004, 21332002)
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