Evidence for production of an inactive collagenase by fibroblasts from phenytoin‐enlarged human gingivae
Author:
- 1 July 1982
- journal article
- research article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 11 (4) , 310-317
Abstract
When measured by radioimmunoassay, fibroblasts derived from the overgrown gingivae of phenytoin‐treated epileptic individuals synthesize and release elevated amounts of collagenase in vitro, as compared to similar‐appearing fibroblasts from normal, non‐phenytoin‐treated persons. However, it appears that much of the immunoreactive enzyme is unable to degrade reconstituted collagen in culture. This preliminary finding in 9 different strains of cells indicates that reduced collagenase activity by a subpopulation of cells may contribute to the development of phenytoin‐induced gingival overgrowth.Keywords
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