Role of Nlrp6 and Nlrp12 in the maintenance of intestinal homeostasis
Author:
Open Access
- 13 December 2013
- journal article
- review article
- Published by Wiley in European Journal of Immunology
- Vol. 44 (2) , 321-327
Abstract
There has been significant interest in understanding how interactions between the host immune system and the gut microbiota regulate intestinal homeostasis. Recent data suggest that the Nod‐like receptor (NLR) family of PRRs regulate both the composition of the gut microbiota and innate immune signaling pathways that prevent pathologic intestinal inflammation and tumorigenesis. In this review, we will focus on NLRP6 and NLRP12, two members of the NLR family that have emerged as important players in the maintenance of intestinal homeostasis, and discuss the signaling pathways engaged by these receptors as well as the current models of how these receptors protect against the development of colitis and tumorigenesis.Keywords
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