Penasterol, a novel antileukemic sterol from the okinawan marine sponge Penares sp.
Authors:
- Jie-Fei ChengJCJie-Fei Cheng
- Jun'IChi KobayashiJKJun'IChi Kobayashi
- Hideshi NakamuraHNHideshi Nakamura
- Yasushi OhizumiYOYasushi Ohizumi
- Yoshimasa HirataYHYoshimasa Hirata
- Takuma SasakiTSTakuma Sasaki
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 8,p. 2403-2406
Abstract
A novel lanosterol-derived metabolite, penasterol (1), with potent antileukemic activity has been isolated from the Okinawan marine sponge Penares sp. and the structure elucidated on the basis of evidence provided by spectroscopy and chemical transformations. This is the first isolation of a marine sterol with a 14-carboxy group potentially important within the framework of sterol biosynthesis.Keywords
This publication has 2 references indexed in Scilit:
- The characterisation of mollic acid 3β-D-xyloside and its genuine aglycone mollic acid, two novel 1α-hydroxycycloartenoids from combretum molleJournal of the Chemical Society, Perkin Transactions 1, 1985
- The Sterols of Marine Invertebrates: Composition, Biosynthesis, and Metabolites1978