Molecular surveillance of the antifolate-resistant mutation I164L in imported african isolates of Plasmodium falciparum in Europe: sentinel data from TropNetEurop
Authors:
- Ole WichmannOWOle Wichmann
- Tomas JelinekTJTomas Jelinek
- Gabriele Peyerl-HoffmannGPGabriele Peyerl-Hoffmann
- Nikolai MühlbergerNMNikolai Mühlberger
- Martin P GrobuschMGMartin P Grobusch
- Joaquim GasconJGJoaquim Gascon
- Alberto MatteelliAMAlberto Matteelli
- Christoph HatzCHChristoph Hatz
- Hermann LaferlHLHermann Laferl
- Marco SchulzeMSMarco Schulze
- Gerd BurchardGBGerd Burchard
- Saraiva da CunhaSCSaraiva da Cunha
Open Access
- 25 June 2003
- journal article
- research article
- Published by Springer Nature in Malaria Journal
- Vol. 2 (1) , 17
Abstract
Malaria parasites that carry the DHFR-mutation I164L are not only highly resistant to sulfadoxine-pyrimethamine but also to the new antimalarial drug chlorproguanil-dapsone. The spread of this mutation in Africa would result in a public health disaster since there is a lack of effective alternatives that are both affordable and safe. Up to now, this mutation has only been described in Asian and Latin-American countries. The objective of this study was to assess the prevalence of this mutation in African isolates of Plasmodium falciparum that have been imported into Europe through travellers.Keywords
This publication has 30 references indexed in Scilit:
- Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from TanzaniaTransactions of the Royal Society of Tropical Medicine and Hygiene, 2002
- Pyrimethamine/sulfadoxine combination in the treatment of uncomplicated falciparum malaria: relation between dihydropteroate synthase/dihydrofolate reductase genotypes, sulfadoxine plasma levels, and treatment outcome.The American Journal of Tropical Medicine and Hygiene, 2002
- Molecular Markers for Failure of Sulfadoxine‐Pyrimethamine and Chlorproguanil‐Dapsone Treatment ofPlasmodium falciparumMalariaThe Journal of Infectious Diseases, 2002
- Molecular surveillance of drug resistance through imported isolates of Plasmodium falciparum in EuropeMalaria Journal, 2002
- Pyrimethamine–sulfadoxine resistance in Plasmodium falciparum: what next?Trends in Parasitology, 2001
- Towards an Understanding of the Mechanism of Pyrimethamine-Sulfadoxine Resistance in Plasmodium falciparum : Genotyping of Dihydrofolate Reductase and Dihydropteroate Synthase of Kenyan ParasitesAntimicrobial Agents and Chemotherapy, 2000
- Averting a malaria disasterThe Lancet, 1999
- Plasmodium falciparum:Detection of Polymorphisms in theDihydrofolate ReductaseandDihydropteroate SynthetaseGenes by PCR and Restriction DigestionExperimental Parasitology, 1998
- Mutations inPlasmodium falciparumDihydrofolate Reductase and Dihydropteroate Synthase and Epidemiologic Patterns of Pyrimethamine‐Sulfadoxine Use and ResistanceThe Journal of Infectious Diseases, 1997
- Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparumMolecular and Biochemical Parasitology, 1995