Anti-inflammatory Labdane Diterpenoids from Leonurus macranthus

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Abstract
Twenty new polyoxygenated labdane diterpenoids (1–20) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The absolute configurations of macranthin A (1) and 6-O-deacetylmacranthin A (2) were determined by single-crystal X-ray crystallographic analysis and a modified Mosher’s method, respectively. Compounds 1–9, 12, 14, and 19 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC50 values of 10.0–63.7 μM.
Funding Information
  • the United States Department of Agriculture, ARS, Specific Cooperative Agreement (58-6408-2-009)
  • National Key Technology R&D Program ?New Drug Innovation? of China (2013ZX09402201001, to J.L.)
  • Program for New Century Excellent Talents in University (NCET-13-0693, to J.L.)
  • TCM support project from the Ministry of Industry and Information Technology of P.R. China (2013060 to J.L.)

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