Leishmanicidal Evaluation of Novel Synthetic Chromenes
Authors:
- 21 November 2008
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 341 (12) , 787-793
Abstract
In the present paper, twelve chromenes were synthesized by coupling of 2,2,8,8‐tetramethyl‐8H‐pyrano[2,3‐f]chroman‐4‐one 1 with various aryl and benzylmagnesium chlorides. The synthetic compounds were examined for in‐vitro activity against Leishmania major, and some of them displayed efficient anti‐leishmanial activity. Among the compounds tested, compounds 9 (4‐(2‐chloro‐benzylidene)‐2,2,8,8‐tetramethyl‐3,4‐dihydro‐2H,8H‐pyrano[2,3‐f]chromene 9a and 4‐(2‐chloro‐benzyl)‐2,2,8,8‐tetramethyl‐2H,8H‐pyrano[2,3‐f]chromene 9b) were the most active with an inhibitory activity of 73.4%.Keywords
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