A Feasible Strategy of Fabricating Type I Photosensitizer for Photodynamic Therapy in Cancer Cells and Pathogens

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Abstract
The utilization of photochemical reaction channel based on radical process is rarely reported, which might be a very efficient and feasible strategy for improving generation of Type I reactive oxygen species (ROS). In this work, a double ionic-type aggregation-induced emission luminogen (AIEgen) of TIdBO was developed as a photosensitizer, of which the potential photocyclization characteristic involving an electron-transfer process had a positive effect on Type I ROS generation in aggregates under continuous light irradiation. Its noticeable photodynamic therapy (PDT) performance and self-monitoring of PDT process by the relationship between cellular morphology change and fluorescence intensity enhancement were achieved. In addition, it showed a good killing ability to microbes and specific interactions with microbes but not cells by regulating the incubation time. These intriguing results reveal a feasible design principle for the implementation of efficient PS preparation in clinical treatment under hypoxic conditions.
Funding Information
  • Ministry of Education of the People's Republic of China (2019ZD04)
  • Ministry of Science and Technology of the People's Republic of China (2017YFE0132200)
  • Innovation and Technology Commission (ITC-CNERC14SC01)
  • National Natural Science Foundation of China (21788102, 21975077, 51673118)
  • Military Logistics Support Department (BLB19J008)
  • Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province, South China University of Technology (2019B030301003)

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