Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution.
Authors:
Open Access
- 1 December 1991
- journal article
- Published by Rockefeller University Press in Journal of Experimental Medicine
- Vol. 174 (6) , 1657-1660
Abstract
We have previously found that a Tyr residue was critical for the interaction of peptides with the Kd molecule, and therefore may be acting as an anchor residue. In the present report we show that it is possible to convert a self peptide sequence into a Kd-restricted neo-antigen by a single Tyr substitution at position 2 of the peptide. This supports the idea that Tyr is a critical element in the binding motif of Kd-restricted peptides and is a finding that could also prove useful for vaccine development.Keywords
This publication has 14 references indexed in Scilit:
- The identification of tyrosine as a common key residue in unrelated H-2Kd restricted antigenic peptidesInternational Immunology, 1991
- Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells.Journal of Experimental Medicine, 1989
- Structure of the gene of tum− transplantation antigen P91A: The mutated exon encodes a peptide recognized with Ld by cytolytic T cellsCell, 1989
- Antigen Recognition by Class I-Restricted T LymphocytesAnnual Review of Immunology, 1989
- Synthetic T and B Cell Recognition Sites: Implications for Vaccine Development1989
- Genes Coding for T-cell-defined Tum Transplantation Antigens: Point Mutations, Antigenic Peptides, and Subgenic ExpressionCold Spring Harbor Symposia on Quantitative Biology, 1989
- The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigensNature, 1987
- Structure of the human class I histocompatibility antigen, HLA-A2Nature, 1987
- H2-restricted recognition of cloned HLA class I gene products expressed in mouse cells.The Journal of Immunology, 1986
- Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. III. Clonal analysis of the syngeneic cytolytic T lymphocyte responseEuropean Journal of Immunology, 1982