Two pairs of phenylpropanoid enantiomers from the leaves of Eucommia ulmoides
- 12 July 2018
- journal article
- research article
- Published by Taylor & Francis in Journal of Asian Natural Products Research
- Vol. 20 (11) , 1045-1054
Abstract
Two pairs of phenylpropanoid enantiomers, (+)-(7S,8S)-alatusol D (1a), (−)-(7R,8R)-alatusol D (1b), (−)-(7S,8R)-alatusol D (2a) and (+)-(7R,8S)-alatusol D (2b) were isolated from the leaves of Eucommia ulmoides Oliver. Among them, 1a and 2b were firstly obtained by chiral enantiomeric resolution. Their structures were elucidated based on extensive spectroscopic analysis and the induced CD (ICD) spectrum caused by adding Mo2(AcO)4 in DMSO. All compounds were tested on Hep G2 tumor cell lines. However, none of the compounds showed potential cytotoxic activity against Hep G2 in vitro.Keywords
Funding Information
- National Natural Science Foundation of China (No. 81303180)
- National Natural Science Foundation of China (81303180)
- State Key Program of National Natural Science of China (No. 81430095)
- State Key Program of National Natural Science of China (81430095)
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