Human Vγ9/Vδ2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1)

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Abstract
The killer cell lectin-like receptor G1 (KLRG1) is expressed in natural killer (NK) cells and effector memory αβ T cells. γδ T cells represent an unconventional lymphocyte population that shares characteristics of NK cells and T cells and links innate and adaptive immunity. Vγ9/Vδ2 T cells comprise the majority of peripheral human γδ T cells and respond to the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Here, we demonstrate that KLRG1 is expressed in a significant proportion of Vγ9/Vδ2 T cells in cord blood and in the majority of peripheral Vγ9/Vδ2 T cells from adult donors. KLRG1+ Vγ9/Vδ2 T cells displayed an effector memory phenotype, as KLRG1 was expressed mainly in Vγ9/Vδ2 T cells lacking CD27, CD45RA, CD62L, and CC chemokine receptor 7 (CCR7). Unlike αβ T cells, where possession of KLRG1 identified effector memory cells with impaired proliferative capacity, KLRG1+ Vγ9/Vδ2 T cells were able to proliferate vigorously upon stimulation with HMB-PP in the presence of interleukin-2. Moreover, KLRG1 ligation on Vγ9/Vδ2 T cells by antibodies did not inhibit HMB-PP-induced proliferation and cytokine production nor cytolysis of Daudi cells.
Funding Information
  • Else Kröner-Fresenius-Stiftung
  • Fonds der Chemischen Industrie
  • Deutsche Forschungsgemeinschaft (SFB620)
  • Institut für Klinische Immunologie und Transfusionsmedizin
  • Universitätsklinikum Giessen

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