Transmission Clustering Drives the Onward Spread of the HIV Epidemic Among Men Who Have Sex With Men in Quebec
Authors:
- Bluma G. BrennerBluma G. Brenner
- David StephensDavid Stephens
- the Montreal PHI Cohort Study GroupTGthe Montreal PHI Cohort Study Group
Open Access
- 1 October 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 204 (7) , 1115-1119
Abstract
Phylodynamic analysis and epidemiologic data identified 3 patterns of spread of primary human immunodeficiency virus type 1 infection (PHI) among men who have sex with men (2001–2009): 420 unique PHIs, 102 small clusters (2–4 PHIs per cluster, n = 280), and 46 large clusters (5–31 PHIs per cluster, n = 450). Large clusters disproportionately increased from 25.2% of PHIs in 2005 to 39.1% in 2009 (χ2 = 33.9, P < .001). Scalar expansion of large clusters over 11 months (interquartile range, 3.5–25.5 months) correlated with cluster membership size (r2 = 0.174, F = 4.424, P = .047). PHI cohort data revealed variations in social networks and risk behaviors among the 3 groups, suggesting the need for tailored prevention measures.Keywords
This publication has 17 references indexed in Scilit:
- Determinants of HIV-1 transmission in men who have sex with men: a combined clinical, epidemiological and phylogenetic approachAIDS, 2010
- Antiretroviral treatment of primary HIV infection to reduce onward transmissionCurrent Opinion in HIV and AIDS, 2010
- Molecular Epidemiology Reveals Long‐Term Changes in HIV Type 1 Subtype B Transmission in SwitzerlandThe Journal of Infectious Diseases, 2010
- Transmission networks of HIV-1 among men having sex with men in the NetherlandsAIDS, 2010
- Molecular Phylodynamics of the Heterosexual HIV Epidemic in the United KingdomPLOS Pathogens, 2009
- Bayesian Phylogeography Finds Its RootsPLOS Computational Biology, 2009
- Transmission networks of drug resistance acquired in primary/early stage HIV infectionAIDS, 2008
- Episodic Sexual Transmission of HIV Revealed by Molecular PhylodynamicsPLOS Medicine, 2008
- Determinants of HIV Seroconversion Among Men Who Have Sex With Men Living in a Low HIV Incidence Population in the Era of Highly Active Antiretroviral TherapiesSexually Transmitted Diseases, 2008
- Bayesian Coalescent Inference of Past Population Dynamics from Molecular SequencesMolecular Biology and Evolution, 2005