A Randomized Trial of the Efficacy and Tolerability of the COX-2 Inhibitor Rofecoxib vs Ibuprofen in Patients With Osteoarthritis
Authors:
- Briggs MorrisonBMBriggs Morrison
- Armando LuzaALArmando Luza
- Oswaldo CastanedaOCOswaldo Castaneda
- Alberto StrusbergASAlberto Strusberg
- Menachem NahirMNMenachem Nahir
- Knut Bjorn HelgetveitKHKnut Bjorn Helgetveit
- Barbara KressBKBarbara Kress
- Brian DanielsBDBrian Daniels
- James BologneseJBJames Bolognese
- Dave KrupaDKDave Krupa
- Beth SeidenbergBSBeth Seidenberg
Open Access
- 26 June 2000
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 160 (12) , 1781-1787
Abstract
NONSTEROIDAL anti-inflammatory drugs (NSAIDs) are commonly used to treat the pain and inflammation caused by a variety of clinical disorders, including osteoarthritis (OA). The clinical effects of these drugs result primarily from the inhibition of the enzyme cyclooxygenase (COX), the first step in the conversion of arachidonic acid to prostaglandins.1Keywords
This publication has 20 references indexed in Scilit:
- Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient MiceCell, 1997
- Localization of cyclooxygenase-1 and -2 in adult and fetal human kidney: implication for renal functionAmerican Journal of Physiology-Renal Physiology, 1997
- Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tractsGastroenterology, 1996
- COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex.Proceedings of the National Academy of Sciences, 1996
- Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoidsNeuron, 1993
- cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.Proceedings of the National Academy of Sciences, 1992
- Prostaglandin endoperoxide synthase: regulation of enzyme expressionBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991
- Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.Proceedings of the National Academy of Sciences, 1991
- Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells.Proceedings of the National Academy of Sciences, 1991
- Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like DrugsNature New Biology, 1971