Hepatic Alarmins and Mitochondrial Dysfunction under Residual Hyperlipidemic Stress Lead to Irreversible NAFLD
Open Access
- 14 July 2022
- journal article
- research article
- Published by Xia & He Publishing in Journal of Clinical and Translational Hepatology
- Vol. 000 (000) , 000
Abstract
Nonalcoholic fatty liver disease (NAFLD) includes a range of progressive disorders generated by excess lipid accumulation in the liver leading to hepatic steatosis and eventually fibrosis. We aimed to identify by high performance mass spectrometry-based proteomics the main signaling pathways and liver proteome changes induced by hypercholesterolemia in a rabbit atherosclerotic model that induced high accumulation of lipids in the liver.Keywords
This publication has 27 references indexed in Scilit:
- Alarmins in chronic noncommunicable diseases: Atherosclerosis, diabetes and cancerJournal of Proteomics, 2017
- The role of mitochondria in metabolism and cell deathBiochemical and Biophysical Research Communications, 2017
- Fibronectin expression is critical for liver fibrogenesis in vivo and in vitroMolecular Medicine Reports, 2016
- Free Fatty Acids Increase Intracellular Lipid Accumulation and Oxidative Stress by Modulating PPARα and SREBP‐1c in L‐02 CellsLipids, 2016
- Rabbit models for the study of human atherosclerosis: From pathophysiological mechanisms to translational medicinePharmacology & Therapeutics, 2015
- Functions of Galectin-3 and Its Role in Fibrotic DiseasesThe Journal of Pharmacology and Experimental Therapeutics, 2014
- Nonalcoholic Fatty Liver Disease: Pathogenesis and Therapeutics from a Mitochondria-Centric PerspectiveOxidative Medicine and Cellular Longevity, 2014
- Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patientsEndocrine, 2014
- TNFα-induced lysosomal membrane permeability (LMP) is downstream of MOMP and triggered by caspase-mediated p75 cleavage and ROS formationJournal of Cell Science, 2013
- Expression, localization and alternative splicing pattern of fibronectin messenger RNA in fibrotic human liver and hepatocellular carcinomaJournal of Hepatology, 1997