Brain Connectivity Abnormalities Predating the Onset of Psychosis

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Abstract
Abnormal functional integration among brain areas has been proposed as a pathophysiologic hallmark of psychosis.1,2 Indeed, recent studies,3,4 which estimated effective connectivity from functional magnetic resonance imaging (fMRI) data, reported dysfunctional integration of regional brain activity in patients with psychoses. The extent of this dysconnectivity has often been linked to the severity of psychotic symptoms,5,6 suggesting a mechanistic relation between the degree of functional network integrity and the clinical expression of schizophrenia.2

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