Is the molten globule a third phase of proteins?
- 17 February 1998
- journal article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 95 (4) , 1490-1494
Abstract
The equilibrium properties of proteins are studied by Monte Carlo simulation of two simplified models of protein-like heteropolymers. These models emphasize the polymeric entropy of the fluctuating polypeptide chain. Our calculations suggest a generic phase diagram that contains a thermodynamically distinct “molten globule” state in addition to a rigid native state and a nontrivial unfolded state. The roles of side-chain packing and loop entropy are discussed.Keywords
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