Prevalence of lethal osteochondrodysplasias in Denmark
Author:
- 1 April 1989
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 32 (4) , 484-489
Abstract
The point prevalence at birth of lethal osteochondrodysplasias in a subregion of Denmark was estimated by a study of all children born January 1970 through December 1983. Two cases of thanatophoric dysplasia, one case of thanatophoric dysplasia with cloverleaf skull, two cases of micromelic bone dysplasia with cloverleaf skull, two cases of achondrogenesis type III, and three cases of achondrogenesis type IV were found. Two cases were unclassifiable due to lack of radiographs. In total, the point prevalence at birth was 15.4 per 100,000. Thus lethal Osteochondrodysplasias seem to be more common than is generally assumed.The clinical and radiographic findings in micromelic bone dysplasia with cloverleaf skull are discussed in relation to thanatophoric dysplasia and achondrogenesis type IV.Keywords
This publication has 17 references indexed in Scilit:
- Cloverleaf Skull and Bone Dysplasias (Report of four cases)Australasian Radiology, 1987
- The birth prevalence rates for the skeletal dysplasias.Journal of Medical Genetics, 1986
- Thanatophoric dysplasia: Fetal manifestations and prenatal diagnosisAmerican Journal of Medical Genetics, 1985
- Thanatophoric dysplasia with cloverleaf-skullEuropean Journal of Pediatrics, 1982
- Achondrogenesis type II in twinsBritish Journal of Radiology, 1981
- The so-called ?cloverleaf skull syndrome?Pediatric Radiology, 1974
- Thanatophoric DwarfismJournal of Medical Genetics, 1973
- The cloverleaf skull syndromeVirchows Archiv, 1972
- Achondroplasia and thanatophoric dwarfism in the newbornClinical Genetics, 1971
- Cloverleaf Skull and Thanatophoric DwarfismAustralasian Radiology, 1970