Methadone for critically ill patients under mechanical ventilation in the intensive care unit: a systematic review
Authors:
- Sérgio Martins PereiraSPSérgio Martins Pereira
- Megan AbbottMAMegan Abbott
- João Francisco Figueiredo Marcondes FerrazJFJoão Francisco Figueiredo Marcondes Ferraz
- Akash GoelAGAkash Goel
- Andrea RigamontiARAndrea Rigamonti
- Charmaine de CastroCCCharmaine de Castro
- Lisa BurryLBLisa Burry
- Airton Leonardo de Oliveira ManoelAMAirton Leonardo de Oliveira Manoel
- Michael Chaim SklarMSMichael Chaim Sklar
Open Access
- 15 July 2025
- journal article
- review article
- Published by Associação de Medicina Intensiva Brasileira in Critical Care Science
- Vol. 37, e20250396
Abstract
Purpose: Pain may pose significant challenges in the intensive care unit, especially in mechanically ventilated patients. Methadone has recently emerged as an alternative option for eliciting acute analgesia. In this systematic review, we evaluated the use of methadone in mechanically ventilated patients in the intensive care unit. Source: We searched MEDLINE, EMBASE, Wiley’s Cochrane […] ABSTRACT Purpose: Pain may pose significant challenges in the intensive care unit, especially in mechanically ventilated patients. Methadone has recently emerged as an alternative option for eliciting acute analgesia. In this systematic review, we evaluated the use of methadone in mechanically ventilated patients in the intensive care unit. Source: We searched MEDLINE, EMBASE, Wiley’s Cochrane […]Keywords
This publication has 52 references indexed in Scilit:
- Critical care nurses’ experiences of caring for patients with iatrogenic opioid withdrawal in the intensive care unit: A qualitative studyIntensive and Critical Care Nursing, 2023
- Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort studyThe Lancet Respiratory Medicine, 2023
- Clinical challenges in mechanical ventilationThe Lancet, 2016
- Protocolized Sedation vs Usual Care in Pediatric Patients Mechanically Ventilated for Acute Respiratory FailureJAMA, 2015
- Analgesic, sedative, antipsychotic, and neuromuscular blocker use in Canadian intensive care units: a prospective, multicentre, observational studyCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 2014
- GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tablesJournal of Clinical Epidemiology, 2011
- Cochrane Handbook for Systematic Reviews of Interventions2008
- Delirium in Mechanically Ventilated PatientsJAMA, 2001
- Neuroexcitatory Effects Of Morphine And Hydromorphone: Evidence Implicating The 3‐Glucuronide MetabolitesClinical and Experimental Pharmacology and Physiology, 2000
- N-Methyl-?-Aspartate (NMDA) Receptors, Mu and Kappa Opioid Tolerance, and Perspectives on New Analgesic Drug DevelopmentNeuropsychopharmacology, 1995