Hydron: An Implantable Device for the Delivery of Antitumor Chemotherapy
Authors:
- Myron ArlenMAMyron Arlen
- Joseph W. ScherrerJSJoseph W. Scherrer
- Jack CukiermanJCJack Cukierman
- Fred NaginFNFred Nagin
- Bernard S. LevowitzBLBernard S. Levowitz
- 1 July 1972
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 105 (1) , 100-104
Abstract
Hydron, a hydrophilic polymeric hydrogel, has been shown to absorb and elute fluorouracil at predetermined rates in vitro. Fluorouracil-charged Hydron pledgets were found to significantly suppress Ehrlich's ascites tumor in CF1 mice compared with controls receiving nonmedicated implants of polymer. An implantable chamber was designed to provide sustained selective release of fluorouracil. Preliminary studies showed the unit was able to deliver high concentrations of the antitumor agent locally while completely sparing tissues remote from the implant site.Keywords
This publication has 2 references indexed in Scilit:
- A New Hydrophilic Polymer as a Common Duct ReplacementArchives of Surgery, 1969
- A furnace for combustion of biological material containing tritium and carbon-14 labeled compoundsAnalytical Biochemistry, 1968