Histological evaluation of Accell Connexus® and Bio-Oss® on quality and rate of bone healing: a single blind experimental study on rabbit’s calvarium

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Abstract
The objective of this study was to evaluate the effect of Accell Connexus® on the quality and rate of healing in experimental defects of rabbit calvarium compared to Bio-Oss®. Twelve 2.5–3.5 kg weighing New Zealand white rabbits were used. Three defects (3×6 mm) were created in the cranium of the animals subsequently filled with Accell Connexus®, Bio-Oss® or served as controls. The animals were sacrificed four, six and eight weeks postoperatively and the histology blocks were studied in terms of inflammation, trabeculation thickness, bone type regeneration, foreign body and remained biomaterial by light microscope. The data were subject to Mann-Whitney U test. Increased inflammatory reaction, foreign body reaction, delayed bone formation and lower rate of ossification were observed in DBM-filled defects compared to Bio-Oss® or controls. However, no significant differences were observed in bone formation between Bio-Oss®, Accell Connexus® and control specimens in the three time intervals. Furthermore, no significant differences were noted between Bio-Oss® and control groups. Accell Connexus® showeda lower rate of ossification and bone healing compared to Bio-Oss® or controlgroups. Other studies in this field seem necessary.

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