THE GENETICS OF THE HL‐A SYSTEM IN A CAUCASIAN AUSTRALIAN POPULATION AND ITS RELATIONSHIP TO RENAL TRANSPLANTATION

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Abstract
Summary: The well defined antigens HL‐A1, ‐A2, ‐A3, ‐A5, ‐A7, ‐A8, ‐A9 and ‐A12 as well as the complex antigens 4a and 4b have been studied in 306 unrelated Individuals and 35 families all of Caucasian Australian extract.The results are compatible with the concept that the HL‐A system is made up of two segregant series of antigens, each series being multiallelic and closely linked. However, the HL‐A antigens from the two series appear to show associations within two groups. As well, each group appears to be associated with the complex antigens 4a and 4b. An alternative hypothesis for the genetic control of the HL‐A antigens is proposed, suggesting that 4a and 4b are precursor substances from which the HL‐A antigens are produced by gene action in a manner analogous to the ABO system in man.These findings imply that matching of unrelated individuals in organ transplantation will be difficult. However, if the hypothesis for the genetic control of HL‐A is valid then matching will be simplified, as it could be based on the precursor groups.
Funding Information
  • National Health and Medical Research Council of Australia
  • Felton Bequest
  • Anti-Cancer Council of Victoria