Neurotrophin-Mediated Rapid Signaling in the Central Nervous System: Mechanisms and Functions
Authors:
- 1 February 2005
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 20 (1) , 70-78
Abstract
Neurotrophins regulate growth, survival, and differentiation of central neurons. In addition to the “classical” effects that are relatively slow neurotrophins also elicit rapid signaling that modulates a variety of cellular functions such as membrane excitability, synaptic transmission, and activity-dependent synaptic plasticity. These rapid actions are mediated mainly through the interaction of Trk receptors with ion channels and ionotropic receptors in the plasma membrane.Keywords
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