Nerve Glucose, Fructose, Sorbitol,myo-Inositol, and Fiber Degeneration and Regeneration in Diabetic Neuropathy
Authors:
- Bruce R. ZimmermanBZBruce R. Zimmerman
- Todd H. VilenTVTodd H. Vilen
- Sharon R. MinnerathSMSharon R. Minnerath
- Jeannine L. KarnesJKJeannine L. Karnes
- Jeffrey K. YaoJYJeffrey K. Yao
- Joseph F. PodusloJPJoseph F. Poduslo
- 1 September 1988
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 319 (9) , 542-548
Abstract
We measured the alcohol sugars in sural nerves from 11 controls, 21 conventionally treated patients with diabetes and neuropathy, and 4 diabetics without neuropathy. The results were related to metabolic control and to clinical, neuropathological, and morphometric abnormalities in the nerves.Keywords
This publication has 44 references indexed in Scilit:
- Prevention of basement membrane thickening in retinal capillaries by a novel inhibitor of aldose reductase, tolrestatDiabetes, 1986
- Glucose-induced Alterations in Nerve Metabolism: Current Perspective on the Pathogenesis of Diabetic Neuropathy and Future Directions for Research and TherapyDiabetes Care, 1985
- Direct immunofluorescence findings in peripheral nerve from patients with diabetic neuropathyAnnals of Neurology, 1985
- Axonal atrophy in sensory nerves of the diabetic BB‐Wistar rat: A possible early correlate of human diabetic neuropathyAnnals of Neurology, 1983
- Oral supplementation of myoinositol: effects on peripheral nerve function in human diabetics and on the concentration in plasma, erythrocytes, urine and muscle tissue in human diabetics and normalsActa Neurologica Scandinavica, 1983
- Sodium- and energy-dependent uptake of myo-inositol by rabbit peripheral nerve. Competitive inhibition by glucose and lack of an insulin effect.Journal of Clinical Investigation, 1982
- Early Stimulation of Phosphatidylcholine Biosynthesis During Wallerian Degeneration of Rat Sciatic NerveJournal of Neurochemistry, 1982
- Nerve lipid abnormalities in human diabetic neuropathy: A correlative studyAnnals of Neurology, 1979
- Influence of dietary myoinositol on nerve conduction and inositol phospholipids in normal and diabetic rats.Journal of Neurology, Neurosurgery & Psychiatry, 1978
- Clinical and histological studies in diabetic neuropathyDiabetologia, 1976