Cognitive Dysfunctions Measured with the MCCB in Deficit and Non-Deficit Schizophrenia

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Abstract
This study compared cognitive domains between deficit schizophrenia (DS) and non-deficit schizophrenia (NDS) patients and healthy controls (HC), analyzing relationships between psychopathological dimensions and cognitive domains. A total of 29 DS patients, 45 NDS patients, and 39 HC subjects participated. Cognitive domains were measured using the Measurement and Treatment Research to Improve Cognition in Schizophrenia Battery. Psychopathological symptoms were evaluated with the Positive and Negative Syndrome Scale. Clinical groups performed poorer than HC groups in regards to speed of processing, attention/vigilance, working memory, verbal and visual learning and memory, reasoning and problem solving, and social cognition. DS patients scored poorer than NDS patients in terms of all cognitive domains and the overall score, except for reasoning and problem solving. Positive, negative, disorganization, and resistance symptoms were related to cognitive functions only in NDS patients. Our findings suggest that the MCCB battery is sensitive to detecting cognitive dysfunctions in both deficit and non-deficit schizophrenia.
Funding Information
  • Pomeranian Medical University in Szczecin (FSN-337-441 06/2016, FNS-246 05/2017, 504-442 3000-240-940/2015/2016, 002/RID/2018/19)
  • Faculty of Humanities at the University of Szczecin (FSN-337-441 06/2016, FNS-246 05/2017, 504-442 3000-240-940/2015/2016, 002/RID/2018/19)
  • Polish Minister of Science and Higher Education’s program named “Regional Initiative of Excellence” 2019–2022 (FSN-337-441 06/2016, FNS-246 05/2017, 504-442 3000-240-940/2015/2016, 002/RID/2018/19)

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