Blood and Tissue Levels of Lipoperoxides in Rats during Development

Authors:
  • TYTamotsu Yoshioka
    Tamotsu Yoshioka
  • MMMariko Mori
    Mariko Mori
  • YTYoshiki Takehara
    Yoshiki Takehara
  • MSMie Shimatani
    Mie Shimatani
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Abstract
The excessive accumulation of lipoperoxides has been accepted as being highly responsible for the development of retinopathy of prematurity and idiopathic respiratory distress syndrome of the newborn infant. We have studied development-related levels of lipoperoxides in blood and tissues such as the liver, lungs, kidneys and brain from birth to adult age using rats as the experimental animal. Lipoperoxide concentrations in blood and tissues were low in the fetal and early newborn periods. The concentrations increased with age and peaked in the early newborn period and gradually decreased as the development progressed. In vitro lipoperoxide formation and accumulation in tissues exhibited a close correlation with in vivo lipoperoxide concentrations, except in the brain.