In Vivo Integrity and Biological Fate of Chelator-Free Zirconium-89-Labeled Mesoporous Silica Nanoparticles

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Traditional chelator-based radio-labeled nanoparticles and positron emission tomography (PET) imaging are playing vital roles in the field of nano-oncology. However, their long-term in vivo integrity and potential mismatch of the biodistribution patterns between nanoparticles and radio-isotopes are two major concerns for this approach. Here, we present a chelator-free zirconium-89 (89Zr, t1/2 = 78.4 h) labeling of mesoporous silica nanoparticle (MSN) with significantly enhanced in vivo long-term (>20 days) stability. Successful radio-labeling and in vivo stability are demonstrated to be highly dependent on both the concentration and location of deprotonated silanol groups (−Si–O–) from two types of silica nanoparticles investigated. This work reports 89Zr-labeled MSN with a detailed labeling mechanism investigation and long-term stability study. With its attractive radio-stability and the simplicity of chelator-free radio-labeling, 89Zr-MSN offers a novel, simple, and accurate way for studying the in vivo long-term fate and PET image-guided drug delivery of MSN in the near future.
Funding Information
  • American Cancer Society (125246-RSG-13-099-01-CCE)
  • U.S. Department of War (W81XWH-11-1-0644)
  • National Cancer Institute (1R01CA169365, P30CA014520)
  • University of Wisconsin-Madison
  • National Institute of Biomedical Imaging and Bioengineering
  • Division of Graduate Education (DGE-1256259)

This publication has 39 references indexed in Scilit: