Study of common functional genetic polymorphisms ofFCGR2A,3Aand3Bgenes and the risk for cryptococcosis in HIV-uninfected patients
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Open Access
- 1 January 2007
- journal article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 45 (6) , 513-518
Abstract
A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05–2.63) and 2.04 (1.06–4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.Keywords
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