Briel Communication : Location by Immunoelectron Microscopy of Carcinoembryonic Antigen on Cultured Adenocarcinoma Cells 2

Authors:
  • RHRonald B. Herberman
    Ronald B. Herberman
  • TATadao Aoki
    Tadao Aoki
  • GCGrace Cannon
    Grace Cannon
  • MLMargaret Liu
    Margaret Liu
  • MSMacie Sturm
    Macie Sturm
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Abstract
The tissue-culture cell line HT-29, derived from a primary colon adenocarcinoma and previously shown to secrete carcinoembryonic antigen (CEA), was examined by immunoelectron microscopy for the location of CEA in relation to the cells. CEA was closely adjacent to the plasma membrane, a location indistinguishable from that of alloantigens and other tumor-associated antigens