Feasibility Study on the Use of Coded Aperture Mask in SPECT for Boron Dose Imaging in TRR-Based BNCT: Preliminary Study

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Abstract
In this work, the feasibility study on using a Coded-Aperture Imaging based on a Modified Uniformly Redundant Array coded mask in Single Photon Emission Computed Tomography (SPECT) was investigated for boron dose measurement in Boron Neutron Capture Therapy (BNCT). In this preliminary study, a MURA rank 13 with a 2×2 mosaic configuration, and a CZT detector array mounted in a single mask were investigated using Monte Carlo Simulation Code, MCNPX2.7. This is the first investigation on the use of Coded-Aperture Imaging for BNCT purposes for boron dose measurement during treatment. Also, the Maximum Likelihood-Expectation Maximization method was used for image reconstruction for boron dose estimation in the tissue. The results were examined for the recommended therapeutic neutron beam in the Tehran research reactor. Preliminary results show that SPECT with Modified Uniformly Redundant Array masks can be an efficient and precise tool for boron dose measurement in BNCT, and results show the superiority of this method in comparison to the conventional SEPCT in BNCT.

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