Effects of Genetic Variations in the Dopaminergic System on Fatigue in Humans: Gender Aspects
- 20 July 2010
- journal article
- genetics
- Published by Springer Nature in Bulletin of Experimental Biology and Medicine
- Vol. 149 (2) , 226-232
Abstract
Changes in the functional status under the effect of intense mental exercise were studied in carriers of different variants of DAT1, DRD2, and COMT genes. The volunteers (n=140) performed 3-h monotonous mental work (information processing and logical problem solving). The degree of fatigue was evaluated before and after exercise by the HAM (Health status– Activity–Moods) and AMF (Acute Mental Fatigue) questionnaires. A signifi cant relationship between the DAT1, DRD2, and COMT gene polymorphism and changes in the mental sphere status were revealed. The effects of these polymorphisms were the most pronounced in girls. The results are discussed within the framework of hypothesis on the effects of changes in the phasic/tonic dopamine proportion on the studied functions.Keywords
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