Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts
Authors:
- Nady BraidyNady Braidy
- Wei-Ping GaiWGWei-Ping Gai
- Ying Hua XuYXYing Hua Xu
- Perminder SachdevPSPerminder Sachdev
- Gilles J GuilleminGilles J Guillemin
- Xing-Mai JiangXJXing-Mai Jiang
- J William O BallardJBJ William O Ballard
- Martin P HoranMHMartin P Horan
- Zhi Ming FangZFZhi Ming Fang
- Beng H ChongBCBeng H Chong
- DanielKam Yin ChanDCDanielKam Yin Chan
Open Access
- 4 October 2013
- journal article
- Published by Springer Nature in Translational Neurodegeneration
- Vol. 2 (1) , 20
Abstract
The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson’s disease (PD). In this study, we show that α-syn can be taken up by primary human cortical neurons, astrocytes and skin-derived fibroblastsin vitro. Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function, leading to cellular degeneration and cell death, provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells.Keywords
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