Longitudinal Multimodal PAM, OCT, and Fluorescence Imaging Tracking of hiPSC-RPE Transplantation in Large Animals with Neurological Degeneration

Authors:

Abstract
We present a multimodal optical imaging platform for in vivo tracking of subretinally transplanted hiPSC-RPE stem cells in a rabbit model. The approach combines photoacoustic microscopy (PAM), optical coherence tomography (OCT), and fluorescence imaging, enhanced with gold nanochains, to monitor cell migration.