Factor VII in Subjects at Risk for Thromboembolism: Activation or Increased Synthesis?

Authors:
  • OLO. Leri
    O. Leri
  • GMG. Macioce
    G. Macioce
  • GFG.M. Ferri
    G.M. Ferri
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Abstract
In this study the preliminary results obtained by investigating factor VII:antigen and activity in 38 subjects with arterial disease of the extremities are reported. The antigen determination (VIl:Ag) was performed by using an inhibitor neutralization assay; factor VII activity (VIl:C) was determined by one-stage assay with human factor VII artificially depleted plasma. All the patients showed increased levels of VIl:C and VIl·Ag compared to the reference population (p < 0.001). There is a significant correlation between VIl:C and VIl:Ag (r = 0.47), but the ratio VIl:C/VIl:Ag is slightly increased. Our results confirm that elevated levels of factor VII are present in patients with tendency to thrombosis.