Association between cardiovascular health and epigenetic aging: a twin study

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Abstract
Objective: To explore the association between life’s essential 8 and epigenetic age based on twins population. Methods: This study included 1030 twins (515 pairs) for cross-sectional analysis and conducted cross-lagged analysis among 294 twins (147 pairs) who participated in both the baseline and follow-up surveys from the Chinese National Twin Registry. LE8 scores were obtained from measurements based on American Heart Association definitions. DNA methylation data were used to calculate epigenetic age metrics, including GrimAA, DamAA and DunedinPACE. Linear mixed-effect models were applied for cross-twin analyses and within-monozygotic-pair analyses. Results: In the cross-sectional analysis, higher LE8 score was associated with slower epigenetic aging (DunedinPACE and DamAA) in both across-twin analyses and within-monozygotic-pair analyses. In stratified analyses, the association between LE8 score and epigenetic age appeared more significant in males and in individuals aged 50 years older. The cross-lagged analysis further revealed significant temporal associations between LE8, health factor, and DunedinPACE. Conclusion: Higher LE8 scores were associated with a deceleration in biological aging.
Funding Information
  • The National Natural Science Foundation of China (82373659, 82073633, and 81573223)
  • the national key Research and Development Program of China (2023YFC2705900)
  • The Beijing Natural Science Foundation (7244455)
  • the Special Fund for Health Scientific Research in the Public Welfare (201502006 and 201002007)
  • the Peking University Outstanding Discipline Construction Project of Epidemiology and Biostatistics

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