Discovery of novel β-carboline/melatonin hybrids as STAT3 inhibitors for the treatment of lung cancer via increasing DNA damage
Authors:
- 6 May 2025
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry
- Vol. 127, 118227
Abstract
No abstract availableKeywords
Funding Information
- Natural Science Foundation of Henan Province (252300420144)
- Natural Science Foundation of Henan Province (JSY-2024Y008)
This publication has 33 references indexed in Scilit:
- WP1066, a small molecule inhibitor of STAT3, chemosensitizes paclitaxel-resistant ovarian cancer cells to paclitaxel by simultaneously inhibiting the activity of STAT3 and the interaction of STAT3 with StathminBiochemical Pharmacology, 2024
- Current Strategies for Extensive Stage Small Cell Lung Cancer Beyond First-line TherapyClinical Lung Cancer, 2022
- Structural hybridization as a facile approach to new drug candidatesBioorganic & Medicinal Chemistry Letters, 2020
- Melatonin modulates airway smooth muscle cell phenotype by targeting the STAT3/Akt/GSK-3β pathway in experimental asthmaCell and tissue research, 2019
- Activated STAT3 may participate in tumor progression through increasing CD133/survivin expression in early stage of colon cancerBiochemical and Biophysical Research Communications, 2018
- Napabucasin: An Update on the First-in-Class Cancer Stemness InhibitorDrugs, 2017
- Spectroscopic and structural studies on the interaction of an anticancer β–carboline alkaloid, harmine with GC and AT specific DNA oligonucleotidesChemico-Biological Interactions, 2016
- Constitutive activation of STAT3 in breast cancer cells: A reviewInternational Journal of Cancer, 2015
- STAT3 regulated ATR via microRNA-383 to control DNA damage to affect apoptosis in A431 cellsCellular Signalling, 2015
- Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitorsEuropean Journal of Medicinal Chemistry, 2015