Abstract
The article describes the working conditions, clinical presentation, immune profile status, and cytokine regulation associated with vibration disease caused by local vibration exposure, both in isolation and in combination with osteoarthritis, among riveters at an aircraft manufacturing plant. The prognostic significance of changes in the immune profile and cytokine regulation in these conditions was established. It was demonstrated that occupational vibration exposure leads to alterations in all quality-of-life indicators; these changes are most pronounced in cases of stage II vibration disease resulting from local vibration exposure combined with osteoarthritis.