FOXM1 cooperates with ERα to regulate functional β-cell mass

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Abstract
Here we investigate why the effects of increasing FOXM1 activity in β-cells observed in male mice are not seen in female mice. ERα likely collaborates with FOXM1 and other transcription factors to enhance gene expression related to β-cell function. Higher estrogen levels in females may contribute to their increased insulin secretion and the more severe consequences of losing transcription factors like FOXM1 in males. Overall, these findings shed light on sex differences in diabetes susceptibility.
Funding Information
  • HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (R01DK110183)
  • American Diabetes Association (7-23-Ibswh-05)

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