Delftia as a small-molecule chassis: lessons from delftibactin and harmane

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Abstract
Delftia spp. occur in diverse environmental and host-associated settings, but their small-molecule capabilities are not uniform across the genus. In this Minireview, we use a strain-resolved “small-molecule chassis” framework to examine cases in which exported, low-molecular-weight metabolites can be linked to extracellular phenotypes. We focus on two anchor systems: delftibactin, a siderophore-like nonribosomal peptide metallophore associated with Au(III) detoxification and gold biomineralization in Delftia acidovorans , and harmane, a β-carboline linked to inhibition of early Plasmodium development by Delftia tsuruhatensis TC1 in mosquitoes. These systems do not represent the same level of mechanistic resolution, with delftibactin providing the tighter genotype→metabolite→phenotype chain and TC1 spanning both a harmane-linked mosquito phenotype and a less resolved low-molecular-weight supernatant phenotype in sand flies. Comparative genomics further supports the idea that these activities are strain- and lineage-specific rather than genus-wide. We argue that the small-molecule chassis framework is most useful not as a blanket label for Delftia , but as a way to identify which strains justify deeper mechanistic study and cautious translation.

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