Inflammasome activation and IL ‐1β signalling in group A Streptococcus disease
Open Access
- 21 June 2021
- journal article
- review article
- Published by Hindawi Limited in Cellular Microbiology
- Vol. 23 (9) , e13373
Abstract
Group A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes significant morbidity and mortality worldwide. Recent clinical evidence suggests that the inflammatory marker interleukin-1β (IL-1β) plays an important role in GAS disease progression, and presents a potential target for therapeutic intervention. Interaction with GAS activates the host inflammasome pathway to stimulate production and secretion of IL-1β, but GAS can also stimulate IL-1β production in an inflammasome-independent manner. This review highlights progress that has been made in understanding the importance of host cell inflammasomes and IL-1 signalling in GAS disease, and explores challenges and unsolved problems in this host-pathogen interaction. Take Away Inflammasome signalling during GAS infection is an emerging field of research. GAS modulates the NLRP3 inflammasome pathway through multiple mechanisms. SpeB contributes to IL-1β production independently of the inflammasome pathway. IL-1β signalling can be host-protective, but also drive severe GAS disease.Keywords
This publication has 84 references indexed in Scilit:
- Reduction of Streptolysin O (SLO) Pore-Forming Activity Enhances Inflammasome ActivationToxins, 2013
- Serine/Threonine Phosphatase (SP-STP), Secreted from Streptococcus pyogenes, Is a Pro-apoptotic ProteinJournal of Biological Chemistry, 2012
- Importance of Toll-Like Receptor 9 in Host Defense against M1T1 Group A Streptococcus InfectionsJournal of Innate Immunity, 2011
- IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβNature Immunology, 2010
- Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF-κB Activation but Proceeds Independently of TLR Signaling and P2X7 ReceptorThe Journal of Immunology, 2009
- Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infectionsProceedings of the National Academy of Sciences, 2009
- Incompetence of Neutrophils to Invasive Group A streptococcus Is Attributed to Induction of Plural Virulence Factors by Dysfunction of a RegulatorPLOS ONE, 2008
- Caspase-1-Mediated Activation of Interleukin-1β (IL-1β) and IL-18 Contributes to Innate Immune Defenses againstSalmonella entericaSerovar Typhimurium InfectionInfection and Immunity, 2006
- Genome-Wide Analysis of Group A Streptococci Reveals a Mutation That Modulates Global Phenotype and Disease SpecificityPLOS Pathogens, 2006
- Viable Group A Streptococci in Macrophages during Acute Soft Tissue InfectionPLOS Medicine, 2006