Intrarectal Diazepam in Epileptic Adults
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Abstract
Summary:Intrarectally (i.r.) administered diazepam (DZP) solution at doses of 20 and 30 mg in the treatment of serial seizures was studied in 39 adult patients with refractory partial epilepsy. Patients were randomly distributed into two groups (20 mg, n = 21; 30 mg, n = 18). Plasma levels of DZP were assessed over 24 h following i.r. injection. The efficacy of i.r. DZP in the treatment of serial seizures in adults was confirmed; onset of effect was noted ∼10 min after the injection, and the effective dose was 0.50 mg/kg. Tolerance and acceptability were good. Intrarectal injection of DZP can be performed even by unskilled personnel and may be recommended in patients with serial seizures in the hope of preventing development of status epilepticus.Keywords
This publication has 10 references indexed in Scilit:
- Intermittent Home Treatment of Status and Clusters of SeizuresEpilepsia, 1989
- Les etats de mal dans le syndrome de Lennox-GastautRevue D'electroencephalographie Et de Neurophysiologie Clinique, 1986
- Essai d'identification d'un syndrome de menace des etats de mal epileptiques chez les epileptiques chroniques en institutionRevue D'electroencephalographie Et de Neurophysiologie Clinique, 1984
- Absorption of Diazepam from the Rectum and Its Effect on Interictal Spikes in the EEGEpilepsia, 1982
- Biopharmaceutics of rectal administration of drugs in man IX. Comparative biopharmaceutics of diazepam after single rectal, oral, intramuscular and intravenous administration in manInternational Journal of Pharmaceutics, 1980
- Absorption of Diazepam in Man Following Rectal and Parenteral AdministrationActa Pharmacologica et Toxicologica, 1979
- Blood levels of diazepam after single rectal administration in infants and childrenThe Journal of Pediatrics, 1978
- Assay of underivatized nitrazepam and clonazepam in plasma by capillary gas chromatography applied to pharmacokinetic and bioavailability studies in humansJournal of Chromatography B: Biomedical Sciences and Applications, 1978
- Polyethylene Glycol as a Solvent for Diazepam: Bioavailability and Clinical Effects after Intramuscular Administration, Comparison of Oral, Intramuscular and Rectal Administration, and Precipitation from Intravenous SolutionsActa Pharmacologica et Toxicologica, 1976
- Clinical Pharmacokinetics of AnticonvulsantsClinical Pharmacokinetics, 1976