ACSS2-KAT5 complex-driven histone crotonylation orchestrates a pro-inflammatory program to promote the transition from MASLD to MASH
Open Access
- 25 July 2026
- journal article
- research article
- Published by Springer Nature in Nature Communications
- Vol. 17 (1) , 9071
Abstract
No abstract availableKeywords
Funding Information
- National Natural Science Foundation of China (82571007, 82370813 to W.H., U22A20272 to Y.D.)
This publication has 76 references indexed in Scilit:
- ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7Advanced Science, 2025
- Acetyl-CoA synthetase 2 alleviates brain injury following cardiac arrest by promoting autophagy in brain microvascular endothelial cellsCellular and Molecular Life Sciences, 2025
- Epigenetics in metabolic dysfunction-associated steatohepatitisCellular Signalling, 2025
- Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseasesAgeing Research Reviews, 2024
- Non‐invasive assessment of hepatic steatosis by ultrasound‐derived fat fraction in individuals at high‐risk for metabolic dysfunction‐associated steatotic liver diseaseDiabetes/Metabolism Research and Reviews, 2024
- Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor developmentDiscover Oncology, 2022
- Allograft inflammatory factor-1 supports macrophage survival and efferocytosis and limits necrosis in atherosclerotic plaquesAtherosclerosis, 2019
- Divergent mechanisms of metabolic dysfunction drive fibroblast and T-cell senescenceAgeing Research Reviews, 2018
- Acyl‐CoA synthetase short‐chain family member 2 (ACSS2) is regulated by SREBP‐1 and plays a role in fatty acid synthesis in caprine mammary epithelial cellsJournal of Cellular Physiology, 2017
- ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic SwitchCell Reports, 2016