Hydrolysis of milk fat globules by pancreatic lipase. Role of colipase, phospholipase A2, and bile salts.
Authors:
- B BorgströmBBB Borgström
- C Erlanson-AlbertssonCEC Erlanson-Albertsson
Open Access
- 1 July 1982
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 70 (1) , 30-32
Abstract
Human milk fat globules require colipase to be hydrolyzed by pancreatic lipase in the presence of bile salts. This is contrary to a recent report in this Journal (J. Clin. Invest. 67: 1748-1752.) according to which inhibition of lipase by bile salt could be overcome by the addition of colipase or phospholipase A2. This latter finding is shown to be due to contamination of commercially available pancreatic phospholipase A2 by colipase.Keywords
This publication has 8 references indexed in Scilit:
- Hydrolysis of human milk fat globules by pancreatic lipase: role of colipase, phospholipase A2, and bile salts.Journal of Clinical Investigation, 1981
- [20] Continuous measurement of free fatty acid release from intact adipocytes by pH-stat titration1981
- Evidence for a pancreatic pro‐colipase and its activation by trypsinFEBS Letters, 1979
- Pancreatic colipase: chemistry and physiology.Journal of Lipid Research, 1979
- Pancreatic and microbial lipases: A comparison of the interaction of pancreatic colipase with lipases of various originsLipids, 1977
- Preparation of Porcine Pancreatic Lipase Free of Co-lipase Activity.Acta Chemica Scandinavica, 1976
- Lipase and co-lipase activities of human small intestinal contents after a liquid test meal.1975
- The Isolation and Properties of Two Prephospholipases A2 from Porcine PancreasEuropean Journal of Biochemistry, 1973