The Influence of Angiotensin II Antagonist Postischemic Acute Renal Failure

Authors:
  • HHH. Huland
    H. Huland
  • HAH.J. Augustin
    H.J. Augustin
  • TET. Engels
    T. Engels
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Abstract
In 34 dogs the effect of a 90-min period of warm ischemia on renal perfusion and function was studied with and without (Sar1, Ile8) angiotensin II treatment. In the first 3 h after the release of renal arterial occlusion, a significant influence of the angiotensin II antagonist on changes in postischemic vascular resistance, intrarenal hemodynamics and renal function could be demonstrated, all being well preserved in the treated group.