Abstract
Journal of Medical Internet Research - International Scientific Journal for Medical Research, Information and Communication on the Internet #Preprint #PeerReviewMe: Warning: This is a unreviewed preprint. Readers are warned that the document has not been peer-reviewed by expert/patient reviewers or an academic editor, may contain misleading claims, and is likely to undergo changes before final publication, if accepted, or may have been rejected/withdrawn. Readers with interest and expertise are encouraged to sign up as peer-reviewer, if the paper is within an open peer-review period. Please cite this preprint only for review purposes or for grant applications and CVs (if you are the author). Background: Adherence to evidence-based therapies such as medications and exercise remains poor among patients after myocardial infarction (MI). Text message reminders have been shown to improve rates of regular medication taking and exercise but existing studies have been of short duration. Objective: Two single-center randomized controlled pilot trials were conducted to evaluate the impact of text message reminders over twelve months on adherence to cardiac medications and exercise among patients receiving cardiac rehabilitation after hospitalization for MI. Methods: In the medication adherence trial, 34 patients were randomized to receive usual care alone or usual care plus daily text message reminders delivered at the time of day at which medications were to be taken. In the exercise adherence trial, 50 patients were randomized to receive usual care alone or usual care plus four daily text messages reminding them to exercise as directed. Results: Text messages led to a mean 14.2 percentage point improvement in self-reported medication adherence over usual care (95% CI 7 – 21). In the exercise trial, text messages resulted in 4.2 (95% CI 1.9 – 6.4) more days and 4.0 hours (95% CI 2.4 – 5.6) of exercise per month over usual care, and a non-significant increase of 1.2 metabolic equivalents or METS (P=0.06) in exercise capacity, as assessed by a BRUCE protocol at 12 months. Conclusions: Text message reminders significantly increased adherence to medication and exercise among post-MI patients receiving care in a structured cardiac rehabilitation program. This technology represents a simple and scalable method to ensure consistent use of evidence-based cardiovascular therapies. Clinical Trial: NCT02783287 at clinicaltrials.gov
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